← Filings of VRTX
Tables in the 10-Q of VERTEX PHARMACEUTICALS INC / MA
43 tables with numbers, filed Aug 4, 2026. Each one downloads as an Excel file or a CSV (numbers are stored as numbers),
with the filing's address in the last row. Only the layout is tidied (a "$" or ")" in a cell of its own is joined to its number); no value is changed.
Open the filing on sec.gov ↗
Table 1 after “TABLE OF CONTENTS”
| | Page |
| Part I. Financial Information | | |
| Item 1. | Financial Statements (unaudited) | 2 |
| Condensed Consolidated Statements of Income | 2 |
| Condensed Consolidated Statements of Comprehensive Income | 3 |
| Condensed Consolidated Balance Sheets | 4 |
| Condensed Consolidated Statements of Shareholders' Equity | 5 |
| Condensed Consolidated Statements of Cash Flows | 6 |
First 8 of 19 rows. The download has all of them.
Table 2 after “(unaudited; in millions, except per share amounts)”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| Revenues: | | | | |
| Product revenues, net | $3,333.9 | $2,944.0 | $6,320.8 | $5,704.2 |
| Other revenues | — | 20.7 | — | 30.7 |
| Total revenues | 3,333.9 | 2,964.7 | 6,320.8 | 5,734.9 |
| Costs and expenses: | | | | |
| Cost of sales | 489.2 | 407.5 | 882.0 | 770.5 |
First 8 of 26 rows. The download has all of them.
Table 3 after “(unaudited; in millions)”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| Net income | $1,099.8 | $1,032.9 | $2,131.2 | $1,679.2 |
| Other comprehensive income (loss): | | | | |
| Unrealized holding (losses) gains on available-for-sale debt securities, net of tax of $4.9, $(2.1), $13.7 and $(6.7), respectively | (17.4) | 7.4 | (48.6) | 23.9 |
| Unrealized gains (losses) on foreign currency forward contracts, net of tax of $(11.2), $54.1, $(35.1) and $79.7, respectively | 39.7 | (191.9) | 124.6 | (282.2) |
| Foreign currency translation adjustment | 1.4 | 15.3 | (11.6) | 29.4 |
| Total other comprehensive income (loss) | 23.7 | (169.2) | 64.4 | (228.9) |
First 8 of 9 rows. The download has all of them.
Table 4 after “(unaudited; in millions, except share and per share data)”
| June 30, 2026 | December 31, 2025 |
| Assets | | |
| Current assets: | | |
| Cash and cash equivalents | $6,143.5 | $5,084.8 |
| Marketable securities | 1,708.9 | 1,523.3 |
| Accounts receivable, net | 2,134.3 | 2,052.8 |
| Inventories | 1,765.1 | 1,686.8 |
| Prepaid expenses and other current assets | 791.9 | 853.3 |
First 8 of 35 rows. The download has all of them.
Table 5 after “(unaudited; in millions)”
| Three Months Ended | | | | | |
| Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Retained Earnings | Total Shareholders’ Equity | |
| Shares | Amount | | | | |
| Balance at March 31, 2025 | 257.0 | $2.6 | $6,172.5 | $68.1 | $10,253.1 | $16,496.3 |
| Other comprehensive loss, net of tax | — | — | — | (169.2) | — | (169.2) |
| Net income | — | — | — | — | 1,032.9 | 1,032.9 |
| Repurchases of common stock | (0.9) | — | (397.3) | — | — | (397.3) |
| Common stock withheld for employee tax obligations | — | — | (5.9) | — | — | (5.9) |
First 8 of 38 rows. The download has all of them.
Table 6 after “(unaudited; in millions)”
| Six Months Ended June 30, | |
| 2026 | 2025 |
| Cash flows from operating activities: | | |
| Net income | $2,131.2 | $1,679.2 |
| Adjustments to reconcile net income to net cash provided by operating activities: | | |
| Stock-based compensation expense | 336.6 | 333.4 |
| Depreciation and amortization expense | 112.4 | 100.1 |
| Intangible asset impairment charge | — | 379.0 |
First 8 of 38 rows. The download has all of them.
Table 7 after “for CRISPR’s share of CRISPR JDCA activities were as follows:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Cost of sales | $21.8 | $30.1 | $44.9 | $66.3 |
| Research and development expenses | $14.4 | $15.1 | $30.5 | $31.1 |
| Acquired in-process research and development expenses | $— | $— | $— | $12.5 |
Table 8 after “per common share for the periods ended:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions, except per share amounts) | | | |
| Net income | $1,099.8 | $1,032.9 | $2,131.2 | $1,679.2 |
| Basic weighted-average common shares outstanding | 253.7 | 256.7 | 253.9 | 256.8 |
| Effect of potentially dilutive securities: | | | | |
| Restricted stock units (including performance-based restricted stock units (“PSUs”)) | 0.9 | 1.3 | 1.2 | 1.4 |
| Stock options | 0.6 | 0.9 | 0.6 | 1.0 |
First 8 of 11 rows. The download has all of them.
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Unvested restricted stock units (including PSUs) | 0.6 | — | 0.3 | — |
| Stock options | — | — | — | — |
| As of June 30, 2026 | As of December 31, 2025 | | | | | | |
| | Fair Value Hierarchy | | Fair Value Hierarchy | | | | |
| Total | Level 1 | Level 2 | Level 3 | Total | Level 1 | Level 2 | Level 3 |
| (in millions) | | | | | | | |
| Financial instruments carried at fair value (asset positions): | | | | | | | | |
| Cash equivalents | $2,656.9 | $1,351.5 | $1,305.4 | $— | $2,779.1 | $1,770.7 | $1,008.4 | $— |
| Marketable securities: | | | | | | | | |
| Corporate equity securities | 11.9 | 11.9 | — | — | 16.6 | 16.6 | — | — |
First 8 of 26 rows. The download has all of them.
Table 11 after “The following table represents a rollforward of the fair value of our contingent consideration liabilities:”
| Six Months Ended June 30, 2026 |
| (in millions) |
| Balance at December 31, 2025 | $79.0 |
| Increase in fair value of contingent payments | 0.6 |
| Balance at June 30, 2026 | $79.6 |
| As of June 30, 2026 | As of December 31, 2025 | | | | | | |
| Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Fair Value | Amortized Cost | Gross Unrealized Gains | Gross Unrealized Losses | Fair Value |
| (in millions) | | | | | | | |
| Cash equivalents | $2,656.9 | $— | $— | $2,656.9 | $2,779.1 | $— | $— | $2,779.1 |
| Marketable securities: | | | | | | | | |
| U.S. Treasury securities | 1,668.0 | 0.4 | (8.0) | 1,660.4 | 1,852.9 | 12.1 | (0.1) | 1,864.9 |
| U.S. government agency securities | 191.0 | 0.2 | (0.4) | 190.8 | 261.2 | 1.2 | — | 262.4 |
| Asset-backed securities | 1,236.1 | 1.2 | (3.8) | 1,233.5 | 1,351.1 | 6.0 | (0.1) | 1,357.0 |
First 8 of 15 rows. The download has all of them.
Table 13 after “Amounts in the table above at fair value were classified on our condensed consolidated balance sheets as follows:”
| As of June 30, 2026 | As of December 31, 2025 |
| (in millions) | |
| Cash and cash equivalents | $2,656.9 | $2,779.1 |
| Marketable securities | 1,708.9 | 1,523.3 |
| Long-term marketable securities | 5,789.1 | 5,712.3 |
| Total | $10,154.9 | $10,014.7 |
Table 14 after “Marketable available-for-sale debt securities by contractual maturity were as follows:”
| As of June 30, 2026 | As of December 31, 2025 |
| (in millions) | |
| Matures within one year | $1,697.0 | $1,506.7 |
| Matures after one year through five years | 5,689.5 | 5,595.8 |
| Matures after five years | 99.6 | 116.5 |
| Total | $7,486.1 | $7,219.0 |
Table 15 after “period were as follows:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Net unrealized (losses) gains | $(8.5) | $6.4 | $(4.7) | $(8.6) |
Table 16 after “component:”
| | Unrealized Holding Gains (Losses), Net of Tax | | |
| Foreign Currency Translation Adjustment | On Available-For-Sale Debt Securities | On Foreign Currency Forward Contracts | Total |
| (in millions) | | | |
| Balance at December 31, 2025 | $37.2 | $34.0 | $(87.1) | $(15.9) |
| Other comprehensive (loss) income before reclassifications | (11.6) | (49.1) | 96.7 | 36.0 |
| Amounts reclassified from accumulated other comprehensive income (loss) | — | 0.5 | 27.9 | 28.4 |
| Net current period other comprehensive (loss) income | (11.6) | (48.6) | 124.6 | 64.4 |
| Balance at June 30, 2026 | $25.6 | $(14.6) | $37.5 | $48.5 |
First 8 of 13 rows. The download has all of them.
Table 17 after “contracts designated as cash flow hedges under U.S. GAAP:”
| As of June 30, 2026 | As of December 31, 2025 |
| Foreign Currency | (in millions) | |
| Euro | $3,520.1 | $4,677.9 |
| Canadian dollar | 371.7 | 516.1 |
| British pound sterling | 351.6 | 492.6 |
| Australian dollar | 278.0 | 267.5 |
| Swiss franc | 91.2 | 126.0 |
| Total foreign currency forward contracts | $4,612.6 | $6,080.1 |
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Designated as hedging instruments - Reclassified from AOCI | | | | |
| Product revenues, net | $(10.2) | $(21.3) | $(35.7) | $2.8 |
| Not designated as hedging instruments | | | | |
| Other income (expense), net | $(13.4) | $(3.1) | $(16.3) | $(4.3) |
| Total reported in the Condensed Consolidated Statements of Income | | | | |
First 8 of 10 rows. The download has all of them.
Table 19 after “flow hedges under U.S. GAAP included on our condensed consolidated balance sheets:”
| As of June 30, 2026 | | | |
| Assets | Liabilities | | |
| Classification | Fair Value | Classification | Fair Value |
| (in millions) | | | |
| Prepaid expenses and other current assets | $60.8 | Other current liabilities | $(35.2) |
| Other assets | 39.9 | Other long-term liabilities | (17.4) |
| Total assets | $100.7 | Total liabilities | $(52.6) |
Table 20 after “flow hedges under U.S. GAAP included on our condensed consolidated balance sheets:”
| As of December 31, 2025 | | | |
| Assets | Liabilities | | |
| Classification | Fair Value | Classification | Fair Value |
| (in millions) | | | |
| Prepaid expenses and other current assets | $6.2 | Other current liabilities | $(79.4) |
| Other assets | 12.7 | Other long-term liabilities | (51.0) |
| Total assets | $18.9 | Total liabilities | $(130.4) |
Table 21 after “designated as cash flow hedges under U.S. GAAP on our condensed consolidated balance sheets:”
| As of June 30, 2026 | | | | |
| Gross Amounts Recognized | Gross Amounts Offset | Gross Amounts Presented | Gross Amounts Not Offset | Legal Offset |
| Foreign currency forward contracts | (in millions) | | | | |
| Total assets | $100.7 | $— | $100.7 | $(52.6) | $48.1 |
| Total liabilities | (52.6) | — | (52.6) | 52.6 | — |
Table 22 after “designated as cash flow hedges under U.S. GAAP on our condensed consolidated balance sheets:”
| As of December 31, 2025 | | | | |
| Gross Amounts Recognized | Gross Amounts Offset | Gross Amounts Presented | Gross Amounts Not Offset | Legal Offset |
| Foreign currency forward contracts | (in millions) | | | | |
| Total assets | $18.9 | $— | $18.9 | $(18.9) | $— |
| Total liabilities | (130.4) | — | (130.4) | 18.9 | (111.5) |
Table 23 after “following:”
| As of June 30, 2026 | As of December 31, 2025 |
| (in millions) | |
| Raw materials | $233.0 | $259.8 |
| Work-in-process | 1,253.9 | 1,196.9 |
| Finished goods | 278.2 | 230.1 |
| Total | $1,765.1 | $1,686.8 |
Table 24 after ““Other intangible assets, net” consisted of the following:”
| | As of June 30, 2026 | As of December 31, 2025 | | | | |
| Estimated Useful Lives | Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount | Gross Carrying Amount | Accumulated Amortization | Net Carrying Amount |
| | (in millions, except useful lives) | | | | | |
| In-process research and development | Indefinite | $224.6 | $— | $224.6 | $224.6 | $— | $224.6 |
| Finite-lived intangible assets - marketed products | 10 to 12 years | 238.0 | (52.2) | 185.8 | 238.0 | (42.1) | 195.9 |
| Finite-lived intangible assets - assembled workforce | 3 years | 7.7 | (5.3) | 2.4 | 7.7 | (4.0) | 3.7 |
| Total other intangible assets, net | | $470.3 | $(57.5) | $412.8 | $470.3 | $(46.1) | $424.2 |
Table 25 after “expense:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Stock-based compensation expense by type of award: | | | | |
| Restricted stock units (including PSUs) | $165.9 | $162.9 | $332.4 | $326.3 |
| ESPP share issuances | 5.8 | 7.1 | 9.2 | 12.7 |
| Stock options | 2.2 | 1.2 | 2.2 | 1.2 |
| Stock-based compensation expense related to inventories | (3.7) | (3.9) | (7.2) | (6.8) |
First 8 of 16 rows. The download has all of them.
Table 26 after “income taxes.”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions, except percentages) | | | |
| Income before provision for income taxes | $1,391.8 | $1,283.0 | $2,644.7 | $2,013.4 |
| Provision for income taxes | $292.0 | $250.1 | $513.5 | $334.2 |
Table 27 after “consisted of the following:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| TRIKAFTA/KAFTRIO | $2,497.2 | $2,551.1 | $4,851.9 | $5,086.6 |
| ALYFTREK | 573.6 | 156.8 | 998.0 | 210.7 |
| Other CF product revenues (1) | 137.1 | 193.7 | 273.0 | 349.0 |
| Total CF product revenues, net | 3,207.9 | 2,901.6 | 6,122.9 | 5,646.3 |
| CASGEVY | 76.4 | 30.4 | 119.3 | 44.6 |
First 8 of 11 rows. The download has all of them.
Table 28 after “consisted of the following:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| United States | $2,056.4 | $1,848.2 | $3,832.3 | $3,511.7 |
| Outside of the United States | | | | |
| Europe | 977.7 | 910.9 | 1,927.7 | 1,737.5 |
| Other | 299.8 | 205.6 | 560.8 | 485.7 |
| Total revenues outside of the United States | 1,277.5 | 1,116.5 | 2,488.5 | 2,223.2 |
First 8 of 9 rows. The download has all of them.
Table 29 after “Significant segment expenses are set forth in the following table:”
| Three Months Ended June 30, | Six Months Ended June 30, | | |
| 2026 | 2025 | 2026 | 2025 |
| (in millions) | | | |
| Total revenues | $3,333.9 | $2,964.7 | $6,320.8 | $5,734.9 |
| Costs and expenses: | | | | |
| Cost of sales - products | 218.3 | 140.5 | 378.5 | 271.1 |
| Cost of sales - royalty | 270.9 | 267.0 | 503.5 | 499.4 |
| Research expenses | 207.3 | 209.3 | 412.3 | 415.4 |
First 8 of 17 rows. The download has all of them.
Table 30 after “consolidated statements of cash flows consisted of the following:”
| Six Months Ended June 30, | | | |
| 2026 | 2025 | | |
| Beginning of period | End of period | Beginning of period | End of period |
| (in millions) | | | |
| Cash and cash equivalents | $5,084.8 | $6,143.5 | $4,569.6 | $4,972.2 |
| Prepaid expenses and other current assets | 3.0 | 10.6 | 2.6 | 9.8 |
| Cash, cash equivalents and restricted cash per condensed consolidated statement of cash flows | $5,087.8 | $6,154.1 | $4,572.2 | $4,982.0 |
Table 31 after “Financial Highlights”
| Total Revenues | In the second quarter of 2026, our total revenues increased to $3.3 billion as compared to $3.0 billion in the second quarter of 2025, primarily due to continued performance of our CF therapies and growth from diversification into additional disease areas. |
| Cost of Sales | Our cost of sales as a percentage of our net product revenues increased to 14.7% in the second quarter of 2026 as compared to 13.8% in the second quarter of 2025, as a result of changes in product mix, partially offset by a lower blended royalty rate for our CF medicines. |
| Total R&D, AIPR&D and SG&A Expenses | Our total research and development (“R&D”), acquired in-process research and development expenses (“AIPR&D”) and selling, general and administrative (“SG&A”) expenses increased to $1.6 billion in the second quarter of 2026 as compared to $1.4 billion in the second quarter of 2025, primarily due to increased investment to commercialize our new products. |
| Cash | Our total cash, cash equivalents and marketable securities increased to $13.6 billion as of June 30, 2026 as compared to $12.3 billion as of December 31, 2025 primarily due to cash flows provided by our operating activities, partially offset by repurchases of our common stock. |
Table 32 after “Total Revenues”
| Three Months Ended June 30, | | | Six Months Ended June 30, | | | |
| 2026 | | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | | |
| TRIKAFTA/KAFTRIO | $2,497.2 | | $2,551.1 | (2)% | $4,851.9 | $5,086.6 | (5)% |
| ALYFTREK | 573.6 | | 156.8 | 266% | 998.0 | 210.7 | 374% |
| Other CF product revenues (1) | 137.1 | | 193.7 | (29)% | 273.0 | 349.0 | (22)% |
| Total CF product revenues, net | 3,207.9 | | 2,901.6 | 11% | 6,122.9 | 5,646.3 | 8% |
| CASGEVY | 76.4 | | 30.4 | 151% | 119.3 | 44.6 | 167% |
First 8 of 13 rows. The download has all of them.
Table 33 after “Our total revenues from the U.S. and from ex-U.S. markets were as follows:”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| United States | $2,056.4 | $1,848.2 | 11% | $3,832.3 | $3,511.7 | 9% |
| ex-U.S. | 1,277.5 | 1,116.5 | 14% | 2,488.5 | 2,223.2 | 12% |
| Total revenues | $3,333.9 | $2,964.7 | 12% | $6,320.8 | $5,734.9 | 10% |
Table 34 after “Operating Costs and Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Cost of sales | $489.2 | $407.5 | 20% | $882.0 | $770.5 | 14% |
| Research and development expenses | 993.8 | 978.4 | 2% | 1,955.4 | 1,958.1 | —% |
| Acquired in-process research and development expenses | 21.4 | 2.2 | ** | 21.9 | 22.0 | ** |
| Selling, general and administrative expenses | 582.2 | 424.6 | 37% | 1,075.9 | 821.0 | 31% |
| Intangible asset impairment charge | — | — | ** | — | 379.0 | ** |
First 8 of 11 rows. The download has all of them.
Table 35 after “Research and Development Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Research expenses | $207.3 | $209.3 | (1)% | $412.3 | $415.4 | (1)% |
| Development expenses | 786.5 | 769.1 | 2% | 1,543.1 | 1,542.7 | —% |
| Total research and development expenses | $993.8 | $978.4 | 2% | $1,955.4 | $1,958.1 | —% |
Table 36 after “Research Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Research Expenses: | | | | | | |
| Salary and benefits | $51.3 | $53.1 | (3)% | $106.5 | $106.2 | —% |
| Stock-based compensation expense | 21.2 | 22.5 | (6)% | 42.4 | 44.8 | (5)% |
| Outsourced services and other direct expenses | 71.2 | 71.0 | —% | 137.8 | 144.1 | (4)% |
| Infrastructure costs | 63.6 | 62.7 | 1% | 125.6 | 120.3 | 4% |
First 8 of 9 rows. The download has all of them.
Table 37 after “Development Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Development Expenses: | | | | | | |
| Salary and benefits | $194.1 | $187.3 | 4% | $406.7 | $383.2 | 6% |
| Stock-based compensation expense | 83.2 | 77.1 | 8% | 163.7 | 154.9 | 6% |
| Outsourced services and other direct expenses | 367.7 | 372.5 | (1)% | 693.9 | 752.2 | (8)% |
| Infrastructure costs | 141.5 | 132.2 | 7% | 278.8 | 252.4 | 10% |
First 8 of 9 rows. The download has all of them.
Table 38 after “Acquired In-Process Research and Development Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Acquired in-process research and development expenses | $21.4 | $2.2 | ** | $21.9 | $22.0 | ** |
| | | | ** Not meaningful | | |
Table 39 after “Selling, General and Administrative Expenses”
| Three Months Ended June 30, | | Six Months Ended June 30, | | | |
| 2026 | 2025 | Change | 2026 | 2025 | Change |
| (in millions, except percentages) | | | | | |
| Selling, general and administrative expenses | $582.2 | $424.6 | 37% | $1,075.9 | $821.0 | 31% |
| As of June 30, 2026 | As of December 31, 2025 | Change |
| (in millions, except percentages) | | |
| Cash, cash equivalents and marketable securities: | | | |
| Cash and cash equivalents | $6,143.5 | $5,084.8 | |
| Marketable securities | 1,708.9 | 1,523.3 | |
| Long-term marketable securities | 5,789.1 | 5,712.3 | |
| Total cash, cash equivalents and marketable securities | $13,641.5 | $12,320.4 | 11% |
| Working Capital: | | | |
First 8 of 11 rows. The download has all of them.
Table 41 after “Cash Flows”
| Six Months Ended June 30, | |
| 2026 | 2025 |
| (in millions) | |
| Net cash provided by (used in): | | |
| Operating activities | $2,553.5 | $1,892.0 |
| Investing activities | $(477.7) | $(540.3) |
| Financing activities | $(965.5) | $(1,029.6) |
Table 42 after “Table of Contents”
| Period | Total Number of Shares Purchased | Average Price Paid per Share | Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs (1) | Approximate Dollar Value of Shares that May Yet be Purchased Under the Plans or Programs (1) |
| April 1, 2026 to April 30, 2026 | 375,000 | $436.21 | 375,000 | $2,873,410,086 |
| May 1, 2026 to May 31, 2026 | 366,652 | $434.50 | 366,652 | $2,714,101,470 |
| June 1, 2026 to June 30, 2026 | 292,000 | $452.37 | 292,000 | $2,582,008,580 |
| Total | 1,033,652 | $440.17 | 1,033,652 | $2,582,008,580 |
Table 43 after “Exhibits”
| Exhibit Number | Exhibit Description |
| 2.1^ | Agreement and Plan of Merger by and among Crinetics Pharmaceuticals, Inc., Vertex Pharmaceuticals Incorporated, and Clark Merger Sub, Inc. dated July 6, 2026 (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed with the Securities and Exchange Commission by Crinetics Pharmaceuticals, Inc. on July 6, 2026). |
| 10.1 | Vertex Pharmaceuticals Incorporated 2026 Stock and Option Plan dated (incorporated by reference to Exhibit 99.1 to the Registration Statement on Form S-8 filed with the Securities and Exchange Commission by Vertex Pharmaceuticals Incorporated on May 13, 2026).* |
| 10.2 | Form of Restricted Stock Unit Agreement under the 2026 Stock and Option Plan.* |
| 10.3 | Form of Restricted Stock Unit Agreement (with Performance Conditions) under the 2026 Stock and Option Plan.* |
| 10.4 | Form of Restricted Stock Unit Agreement (for Non-Employee Directors) under the 2026 Stock and Option Plan.* |
| 10.5 | Form of Option Agreement (for Non-Employee Directors) under the 2026 Stock and Option Plan.* |
| 10.6 | Non-Employee Director Deferred Compensation Plan.* |
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